Herc2 iron
Witryna11 kwi 2024 · Although HERC2 could be engaged with an autophagosome through the interaction with NCOA4, a selective cargo receptor for the autophagic turnover of iron … Witrynairon concentration (standard iron concentration in DMEM with 10% FBS); b) in the reduced iron concentration (iron chelation using 50 µM and 100 µM of DFO); and c) …
Herc2 iron
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Witryna2003). Substrates of HERC2, such as XPA, BRCA1, USP33, and FBXL5, relate this E3 ligase to cellular processes such as DNA repair, centrosome structure, and iron metabolism (Garcıa-Cano et al., 2024; Sanchez-Tena et al., 2016). Genetic studies have asso-ciated the HERC2 locus with human pigmentation, neuronal disorders, and … WitrynaRommela czy Pattona. „Hearts of Iron 2” oferuje także atrakcyjny wieloosobowy tryb kooperacji pozwalający graczom na wspólne kierowanie poczynaniami jednego …
Witryna6 cze 2014 · HERC2 interacts with a region of FBXL5 immediately downstream of the F-box domain, and it regulates the basal turnover of FBXL5 rather than its iron … Witryna22 sty 2016 · HERC2 regulates F-box and leucine-rich repeat protein 5 (FBXL5), a subunit of the SCF ubiquitin ligase complex which targets iron regulatory protein 2 …
WitrynaSNP rs12913832 in HERC2 was found to be strongly associated with blue eye colour. SNP associations with hair and skin colour were weaker and genotypes less … Witryna5 paź 2015 · However, the precise role that HERC2, iron, and the ubiquitin system play in regulating NCOA4, and how this is related to NCOA4 autophagic turnover during ferritinophagy remains unexplored. Third, what is the physiological role of NCOA4 in cellular processes that are highly dependent upon iron availability?
WitrynaFBXL5 (F-box and leucine-rich repeat protein 5) is the F-box protein subunit of, and therefore responsible for substrate recognition by, the SCFF BXL5 ubiquitin-ligase complex, which targets iron regulatory protein 2 (IRP2) for proteasomal degradation. IRP2 plays a central role in the maintenance of cellular iron homeostasis in mammals …
Witryna27 mar 2024 · Ferritin is considered the major iron storage protein which maintains a large iron core in its cavity and has ferroxidase activity. There are many types of ferritin particularly in prokaryotes that include the canonical 24-mer FTN molecules, the heme-containing BFR, the smaller 12-mer DPS and the newly recognized EncFtn of … federal government performance ratingsWitryna6 cze 2014 · FBXL5 (F-box and leucine-rich repeat protein 5) is the F-box protein subunit of, and therefore responsible for substrate recognition by, the SCFF BXL5 ubiquitin … federal government performance awardWitryna21 mar 2024 · HERC2 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with HERC2 include Intellectual … decorations for wedding carWitryna10 sie 2024 · HERC2-mediated NCOA4 degradation is iron-dependent. The E3 ubiquitin ligase HERC2 interacts with NCOA4 via a CUL7 domain in an iron-dependent … decorations for the outside of your houseWitryna3 gru 2024 · Elevated iron levels in cells lead to the recognition of iron-bound NCOA4 by the ubiquitin ligase HERC2, which results in the degradation of NCOA4 and the … decorations for the new yearWitryna19 cze 2014 · In 7 patients of Amish or mixed Amish/Mennonite descent with MRT38, Puffenberger et al. (2012) identified a homozygous missense mutation in the HERC2 gene (P594L; 605837.0004).The mutation was found by a combination of homozygosity mapping and exome sequencing. federal government phone directoryHERC2 (ang. hect domain and RCC1-like domain-containing protein ) - ludzki gen w locus 15q13 regulujący ekspresję genu OCA2 . Powoduje to, że ma silny wpływ na barwę oka. Recesywna mutacja w tym genie prowadzi do zahamowania działania genu OCA2, a co za tym idzie osłabienie produkcji melaniny w tęczówce i powstanie niebieskiego koloru oczu. decorations for wedding venues